RECURRENT MISCARRIAGE AND FERTILITY BLOOD TESTS

Recurrent miscariage

A series of batches of blood tests are being conducted to thoroughly examine all hematological male and female risk factors for recurrent miscarriage. This extensive screening aims to identify any potential underlying issues that may contribute to the recurrence of miscarriages.

We offer a range of specialist tests, investigations and early pregnancy support if you’ve had previous miscarriages or you’re concerned about your current or future pregnancy. We also offer emergency scans if you have pain, bleeding or you’re worried. Most of our patients choose to start their care with us by having a specialist consultation to talk through their experience and consider all of the available options.

Recurrent miscarriage, defined as the loss of two or more consecutive pregnancies, is a distressing experience for many couples. While miscarriage is relatively common, with about 15-20% of known pregnancies ending in miscarriage, recurrent miscarriage affects about 1-2% of couples. Understanding the underlying causes of recurrent miscarriage is crucial for developing effective treatment strategies, and fertility blood tests play a significant role in this process.

Causes of Recurrent Miscarriage

Several factors can contribute to recurrent miscarriage, including:

  1. Genetic Factors: Chromosomal abnormalities in the embryo are a leading cause of miscarriage. These abnormalities can arise spontaneously or be inherited from one or both parents.
  2. Uterine Abnormalities: Structural issues in the uterus, such as fibroids, polyps, or a septate uterus, can interfere with embryo implantation and growth.
  3. Hormonal Imbalances: Conditions such as polycystic ovary syndrome (PCOS), thyroid disorders, and luteal phase defects can disrupt the hormonal balance necessary for maintaining a pregnancy.
  4. Immune System Disorders: Autoimmune conditions, such as antiphospholipid syndrome (APS), can increase the risk of blood clots and miscarriage.
  5. Infections: Certain infections can increase the risk of miscarriage by affecting the health of the uterus or the developing fetus.
  6. Lifestyle Factors: Smoking, excessive alcohol consumption, and obesity can negatively impact pregnancy outcomes.

Fertility Blood Tests: A Diagnostic Tool

Fertility blood tests are essential in diagnosing the causes of recurrent miscarriage. These tests provide valuable insights into hormonal levels, genetic factors, and immune system function, helping healthcare providers develop personalized treatment plans. Key fertility blood tests include:

Hormone Level Testing:

    1. Follicle-stimulating hormone (FSH) and Luteinizing Hormone (LH): These tests assess ovarian reserve and ovulation function.
    2. Thyroid Function Tests: These tests measure levels of thyroid hormones (TSH, T3, and T4) to detect thyroid disorders.
    3. Progesterone Levels: This test evaluates the luteal phase to ensure adequate progesterone levels for pregnancy maintenance.

I ) First Batch Bloods  (TAT 15 days)  – £1000

  • CHROMOSOMES (karyotype – TAT 15 days)           –    £400
  • THROMBOPHILIA / APLS SCREEN (TAT 3 days)  –  £500
  1. Lupus Anticoagulant (LUPC £50)
  2. Anticardiolipin Antibodies IgM & IgG (ACAB £50)
  3. Protein C, Protein S Antithrombin III
  4. Factor V Leiden Common Mutation Factor II Prothrombin Common Mutation
  5. MTHFR (Common Variants) (MTHF £150)
  • THYROID PROFILE 1 (TAT 2 days)                       –    £175
  1. Thyroxine – T4 (FT4 £40)
  2. Thyroid Stimulating Hormone – TSH (TSH £40)
  3. Anti Thyroid Peroxidase (TPO) Antibodies (TPEX £70)

11)  Second Batch Bloods  (Day 2-6 following a period – TAT 2 days)     –      £295 

  •  HORMONE PROFILE                                          –      £250
  1. Follicle Stimulating Hormone – FSH (FSH £45)
  2. Luteinising Hormone – LH (LH £45)
  3. DHEAS (DHEA £70)
  4. Testosterone (TEST £55)
  5. SHBG (SHBG £45)
  6. Free Androgen Index (FAI)
  • Prolactin (PROL )                                                    –       £45

111 )   Third batch Bloods  (Repeat after at least 6 weeks – TAT 3 days)                         –        £ 125

  • APLS SCREEN                                                     
  1. Lupus Anticoagulant (LUPC £65)
  2. Anticardiolipin Antibodies IgM & IgG (ACAB £65)

Immune System Testing:

  1. Antiphospholipid Antibodies (aPL): This test detects antibodies associated with APS, a condition linked to recurrent miscarriage.
  2. Natural Killer (NK) Cell Testing: Elevated levels of NK cells can indicate an overactive immune response, which may contribute to miscarriage.
  • Natural Killer Cells (NKC) X 7                                –      £455
  • Y Deletion                                                                 –      £210

Infection Screening: Tests for infections such as toxoplasmosis, cytomegalovirus (CMV), and bacterial vaginosis can help identify and treat infections that may impact pregnancy.

RECURRENT MISCARRIAGE AND FERTILITY BLOOD TESTS PACKAGES
  • Recurrent Miscarriage Female Primer Package – all blood except chromosomes female (1,2,3)  –   £ 1050
  • Recurrent Miscarriage Patient Package – all blood female including chromosomes (1,2,3)   –     £ 1400
  • Recurrent Miscarriage Complete Package – all bloods female & male (1,2,3)   –      £ 1750

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