PrenatalSAFE NIPT

NIPT Screening Information

According to the International Society for Prenatal Diagnosis (ISPD) and the
American College of Medical Genetics and Genomics (ACMG),
non-invasive prenatal testing (NIPT) is recommended as a
first-line screening test for pregnant women of all ages.

While conditions such as Down syndrome (Trisomy 21) are more common in pregnancies where the mother is over 35 years of age, other chromosomal conditions — including
microdeletion syndromes — occur at a similar frequency regardless of maternal age.

The PrenatalSAFE® non-invasive prenatal test screens for a range of
chromosomal aneuploidies, providing reliable and early risk assessment during pregnancy.

Who is this test suitable for?

PrenatalSAFE® is suitable for:

• Maternal age-related risk (≥35 years)
• Ultrasound findings suggestive of chromosomal abnormalities
• Personal or family history of chromosomal aneuploidy
• One partner carrying a balanced chromosome 13 or 21 Robertsonian translocation
• Low-risk pregnancies seeking reassurance

Booking & Payment Information

To secure your appointment at Miracle Inside Diagnostic Scan Centre,
an initial payment is required at the time of booking.

• Phlebotomy & Courier Fee: £35
  (Includes blood collection and DHL courier service to ensure timely delivery to the laboratory)

This payment confirms your appointment. The remaining balance can be paid online after your visit, ensuring a smooth and efficient process for both patients and staff.

Need help? For any questions or assistance regarding payment, please contact our customer service team on

0113 460 8760.

PrenatalSAFE 3

Price: Blood Test Only – £300 | With Ultrasound – £350

This test screens for common chromosomal conditions including Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18) and Patau syndrome (Trisomy 13). A dating scan is included where applicable.

Includes:

• Screening for Trisomy 21, 18 and 13
• 15-minute appointment with a qualified health professional
• A simple blood sample was taken from the mother’s arm
• Available from 10 weeks (singleton pregnancy only)
• Results sent via email

Note: For fetal sex or additional chromosomal screening, please upgrade to PrenatalSAFE 5.

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PrenatalSAFE 5

Price: Blood Test Only – £350 | With Ultrasound – £400

Screens for common trisomies and sex chromosome abnormalities, including Turner syndrome, Klinefelter syndrome, Jacobs syndrome and Trisomy X, with optional dating scan.

Includes:

• Trisomy 21, 18, 13
• Sex chromosome abnormalities
• Fetal sex determination (included)
• 15-minute clinical appointment
• Blood sample collection
• Results emailed to the client

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PrenatalSAFE 5 Plus

Price: Blood Test Only – £450 | With Ultrasound – £500

Includes all features of PrenatalSAFE 5  screening and additional selected microdeletions and chromosomal abnormalities.

Includes:

• Trisomy 21, 18, 13
• Sex chromosome abnormalities
• Fetal sex determination
• Microdeletions panel (6 conditions)

Microdeletions screened:

• DiGeorge syndrome
• 1p36 deletion syndrome
• Angelman syndrome
• Prader-Willi syndrome
• Cri-du-chat syndrome
• Wolf-Hirschhorn syndrome

Key Features:

• Results within 7-10 working days
• Suitable for singleton and twin pregnancies

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PrenatalSAFE Karyo

Price: Blood Test Only – £600 | With Ultrasound – £650

Includes all features of PrenatalSAFE 5 plus screening and additional selected microdeletions and chromosomal abnormalities.

Genome-wide NIPT providing karyotype-level insight. Screens all chromosomes (1–22) in addition to standard trisomies.

• Rare autosomal aneuploidies
• Chromosomal deletions and duplications

Key Features:

• Genome-wide chromosomal screening
• Results within 7-10 working days
• Suitable for singleton and twin pregnancies

Suitable for:

• Maternal age ≥35 years
• Family or personal history of chromosomal abnormalities
• Ultrasound findings suggestive of aneuploidy
• Low-risk pregnancies seeking advanced screening

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PrenatalSAFE Karyo Plus

Price: Blood Test Only – £650 | With Ultrasound – £700

An advanced version of Karyo with additional microdeletion analysis. Genome-wide NIPT with extended microdeletion panel (9 conditions).

Includes everything in PrenatalSAFE Karyo, plus:

Microdeletions include:

• DiGeorge syndrome
• 1p36 deletion syndrome
• Angelman syndrome
• Prader-Willi syndrome
• Cri-du-chat syndrome
• Wolf-Hirschhorn syndrome
• Langer-Giedion syndrome
• Jacobsen syndrome
• Smith-Magenis syndrome

Key Features:

• Results within 9 to 12 working days

• Increased diagnostic depth for complex chromosomal abnormalities

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PrenatalSAFE® (Karyo + GeneSAFE™) COMPLETE

Price: Without Ultrasound – £1200 /with Ultrasound £1250

An advanced version of the Karyo and Genesafe package with additional microdeletion analysis. This package provides a significantly expanded genetic assessment, including inherited and spontaneous mutations. Screens for inherited genetic conditions such as Cystic Fibrosis, Beta-Thalassemia, Sickle Cell Anaemia, and inherited deafness

Genes screened:

CFTR, GJB2, GJB6, HBB

Includes:

• All chromosomal abnormalities (common and rare)
• Deletions and duplications
• Inherited genetic diseases
• De novo genetic mutations

Additional Requirements:

• 1 × maternal blood sample
• 1 × paternal buccal (cheek) swab

Key Features:

• Results within 15 working days
• Suitable for families seeking deep genetic insight

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PrenatalSAFE® COMPLETE Plus

Price: Without  Ultrasound – £1300/ with ultrasound £1350

Includes everything in PrenatalSAFE Complete, plus an enhanced version of the Complete package with added microdeletion screening.  Advanced screening for 44 severe genetic disorders caused by de novo mutations across 25 genes.

These conditions may not be detectable on early ultrasound and can present later in pregnancy.

Genes include:

ASXL1, BRAF, CBL, CHD7, COL1A1, COL1A2, COL2A1, FGFR2, FGFR3, HDAC8, JAG1, KRAS,
MAP2K1, MAP2K2, MECP2, NIPBL, NRAS, NSD1, PTPN11, RAF1, RIT1, SETBP1, SHOC2, SIX3, SOS1

Key Features:

• Broader detection capability

• Suitable for high-detail prenatal genetic screening

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Online Booking System

1. What is the PrenatalSafe NIPT test?

It is a blood test that screens for common chromosomal conditions in an unborn baby by analysing fetal DNA circulating in the mother’s blood. It is highly accurate and safe with no invasive procedures.

2. How does it work?

The test analyses tiny fragments of fetal DNA that naturally cross into the mother’s bloodstream. A blood sample is sent to the lab where advanced technology checks for chromosomal abnormalities.

3. When can the test be done?

The test can typically be performed from 10 weeks of pregnancy onward.

4. What conditions can it detect?

PrenatalSafe screens for Trisomy 21 (Down syndrome), Trisomy 18 (Edwards syndrome), Trisomy 13 (Patau syndrome), and sex chromosome differences depending on the panel ordered.

5. Is the test safe?

Yes. It is non-invasive and poses no risk to the pregnancy as it only requires a simple blood draw.

6. How accurate is it?

PrenatalSafe is highly accurate, with detection rates often above 99% for Down syndrome. However, it is a screening test, not a diagnostic test.

7. Do I need a referral?

In most cases, you do not need a doctor’s referral for private testing. However, speaking with your maternity care team is encouraged.

8. How long do results take?

Results are usually available within 7–10 working days after the lab receives your sample.

9. What do the results mean?

Low risk: No high risk detected for screened conditions; routine care continues.

High risk: Increased likelihood of a condition; diagnostic testing may be recommended.

10. Can it tell the baby’s sex?

Yes, depending on the panel and your preferences. This is optional and should be requested when booking.

11. Is it covered by insurance?

Private testing is usually self-funded. Please check with your provider for details.

12. What if I get a high-risk result?

A high-risk result does not mean your baby definitely has the condition. Further testing is recommended, and your healthcare provider will guide you.

13. Can multiples (twins, triplets) be tested?

Yes, but interpretation may be more complex. This should be discussed at the time of booking.

14. What can affect accuracy?

Factors include low fetal DNA, high maternal weight, recent transfusion or transplant, and multiple pregnancy. In some cases, a repeat sample may be required.

15. How do I book at Miracle Inside?

Call 0113 4608760, book online, or speak to a healthcare professional at our Leeds clinics. A booking deposit is required.

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